One annoyance with Sense 6.0 is the way it lays out app icons in your app drawer. Besides the fact HTC forces you to scroll through apps vertically, the default grid size is 3×4. With this setting, you’re going to spend a lot more time scrolling to find an app.
I recommend changing the setting by tapping on the menu icon (upper right-hand corner) when viewing the app drawer, and selecting Grid Size. There you’ll find an option to change the grid to a more convenient and respectable 4×5.